Charley Johnson
- Quarterback
- St. Louis Cardinals
- Houston Oilkers
- Denver Broncos
- 1961-1975
Billy “White Shoes” Johnson
- Wide Receiver/Punt Returner
- Houston Oilers
- Atlanta Falcons
- Washington Redskins
- 1974-1988
George Blanda
- Chicago Bears
- Houston Oilers
- Oakland Raiders
- 1949-1975
Tim Rossovich
- Linebacker
- Philadelphia Eagles
- San Diego Chargers
- Houston Oilers
- 1968-1976
Bubba Smith
- Defensive Lineman
- Baltimore Colts
- Oakland Raiders
- Houston Oilers
- 1967-1976
Robert Brazile
- Linebacker
- Houston Oilers
- 1975-1984
Houston Oilers/Tennessee Titans Career Interception Leaders
Most Interceptions in Oilers/Titans History
Fred Glick
- Defensive Back
- Chicago Cardinals
- St Louis Cardinals
- Hoiuston Oilers
- 1959-1966
Mark Moseley
- Kicker
- Philadelphia Eagles
- Houston Oilers
- Washington Redskins
- Cleveland Browns
- 1970-1986
Ron McDole
- Defensive End
- St. Louis Cardinals
- Houston Oilers
- Buffalo Bills
- Washington Redskins
- 1961-1978
Charley Hennigan
- Wide Receiver
- Houston Oilers
- 1960-1966
Mel Gray
- Kick/Punt Returner
- New Orleans Saints
- Detroit Lions
- Houston Oilers
- Philadelphia Eagles
- 1986-1997
Ray Childress
- Defensive End
- Houston Oilers
- Dallas Cowboys
- 1985-1996
Tom Dempsey
- Kicker
- New Orleans Saints
- Philadelphia Eagles
- Los Angeles Rams
- Houston Oilers
- Buffalo Bills
- 1969-1979
Ernest Givins
- Wide Receiver
- Houston Oilers
- Jacksonville Jaguars
- 1986-1990