Dave Osborn
- Running Back
- Minnesota Vikings
- Green Bay Packers
- 1965-1976
Merlin Olsen
- Defensive Tackle
- Los Angeles Rams
- 1962-1976
Jim Otto
- Center
- Oakland Raiders
- 1960-1974
Ken O'Brien
- Quarterback
- New York Jets
- Philadelphia Eagles
- 1984-1993
RC Owens
- Wide Receiver
- San Francisco 49ers
- Baltimore Colts
- New York Giants
- 1957-1964
Bill Osmanski
- Fullback
- Chicago Bears
- 1939-1947
John Offerdahl
- Linebacker
- Miami Dolphins
- 1986-1993